The development of advanced biosensors and Instrumentation is a focal point for several of our faculty members. This research ranges from the development of advanced microscopes for imaging of blood vessels, fabrication of implanted and wearable electronics for physiology measurements to the engineering of molecular sensors for detecting specific chemical species. These sensing systems could be combined with therapeutic modality for disease management, including image-guided surgery, closed-loop neuromodulation, and self-regulated drug delivery.