A wide range of fundamental Biomaterials approaches is actively explored for regenerative and medical therapies, offering multiple avenues for clinical applications. These approaches include development of innovative medical devices, artificial organs, advanced methods for disease treatment, and the engineering of cell-biomaterial surface interactions. The foundation of each of these endeavors requires the development of a new class of instructive biomaterials achieved by engineering biological activity into synthetic materials. Instructive biomaterials enable the recreation of native cellular niches with enhanced control and reproducibility compared to their natural counterparts. Our department is at the forefront of this dynamic field, conducting numerous fundamental and applied studies along with translational work in collaboration with clinical partners. These efforts have resulted in numerous disclosures and patents, showcasing our commitment to advancing biomaterials research.