News and Events
News and Events
Seminars
Making it Click: An Approach to N-Heterocycles and Inclusive Excellence
3:30 pm - 4:30 pm
Location: BME 3.204
Speaker: Andre Isaacs, Ph.D.
Associate Professor
Chemistry
College of the Holy Cross
ABSTRACT:
My research interest is centered on a very reliable organic reaction - the copper-catalyzed cycloaddition of sulfonyl azides and terminal alkynes (CuAAC). Differential fragmentation of the resulting 1,2,3-triazole generates ketenimines or rhodium carbenoids which readily engage with a variety of nucleophiles to provide access to heterocycles of interest to the synthetic community. We’ve demonstrated the utility of click chemistry in the synthesis of N-Heterocycles such as indolizines, dihydroisoquinolines and as an approach to beta-lactams.
In the wake of the Covid-19 pandemic, along with rapid technological advancements and shifting generational cultures, educators face unprecedented challenges in sparking the curiosity of budding scientists. This seminar is also dedicated to navigating these challenges with enthusiasm and compassion, as we explore innovative approaches to teaching that will empower the next generation of learners, with special attention to those from historically excluded groups.