Seminars

I will discuss the relation of vascular topology and geometry to the nature of blood flow in cortex. While surface and subsurface vessels form interconnected networks that are robust to occlusions, blockage of even a single penetrating vessel leads to a microstroke that appears similar to those seen in vascular dementia. With regard to dynamics, I will discuss how neuronal control of flow at ultralow frequencies, i.e., ~ 0.1 Hz, justifies the use of resting-state fMRI to infer large-scale brain connections. The role of technological development in brain studies will be emphasized.