In Vivo Cell Tracking

Thursday, December 1, 2011
3:30 pm - 5:00 pm

Location: BME 3.204

Presenter Information.

Intravital microscopy (IVM) provides a means to visualize single cells in live intact animals. It enables the study of cell biology in the context of normal physiology or in disease models.  IVM is particularly useful for tracking cellular dynamics in complex 3D tissue microenvironments and in combination with advances in fluorescence reporters has led to significant new insights into the behaviour of cancer cells and immune cells in vivo. Unexpectedly, we found that intravital 3D imaging is uniquely capable of tracking rare cells such as transplanted hematopoietic stem cells in the bone marrow.  I will describe the multidisciplinary effort to understand the bone marrow microenvironment and the interplay among immune cells, hematopoietic stem cell, and cancer cells at this location.