Nicholas A. Peppas, Sc.D.
Fletcher Stuckey Pratt Chair in Engineering |
|
Nicholas A. Peppas, Sc.D.
Fletcher Stuckey Pratt Chair in Engineering
- Curriculum Vitae
- Department of Biomedical Engineering
Institute for Cellular and Molecular Biology
The University of Texas at Austin
1 University Station, C0400
Austin, Texas 78712-1062
- Lab Website
Research Focus
Biomaterials, Drug and Protein Delivery, Molecular Recognition, Configurational Biomimesis, BioMEMs and Bionanotechnology, Biosensors, Mathematical Biosciences.
Our research contributions have been in several areas of drug delivery, biomaterials, biomolecular engineering, mass transfer, kinetics and reaction engineering, polymers and biomedical engineering. The multidisciplinary approach of his research in biomolecular engineering blends modern molecular and cellular biology with engineering to generate next-generation systems and devices, including bioMEMS with enhanced applicability, reliability, functionality, and longevity. The fundamental studies of his group have provided valuable results on biomaterials design and development.
Our group is known for our work on the preparation, characterization and evaluation of the behavior of compatible, cross linked polymers known as hydrogels, which have been used as biocompatible materials and in controlled release devices, especially in controlled delivery of drugs, peptides and proteins, development of novel biomaterials, biomedical transport phenomena, and biointerfacial problems. Our polymer research has examined fundamental aspects of the thermodynamics of polymer networks in contact with penetrants, the conformational changes of networks under load or in the presence of a diluent, the anomalous transport of penetrants in glassy polymers, and the kinetics of fast UV-polymerization reactions. In the field of controlled release, his group has provided the fundamental basis for a rational development of such systems. In addition, his work has led to a series of novel controlled release systems known as swelling controlled release systems, a series of pH-sensitive devices for drug delivery and a wide range of bio- and mucoadhesive systems. Other biomedical work of his group had dealt with understanding of transport of biological compounds in tissues, analysis of polymer/tissue interactions, and understanding of the behavior of biomembranes.
Selected Publications
- M.H. Smolensky and N.A. Peppas, "Chronobiology, Drug Delivery
and Chronotherapeutics", Adv. Drug Deliv. Revs., 59, 828-851 (2007).
- D.E.
Owens III, J. K. Eby,
Y. Jian and N. A. Peppas, "Temperature-Responsive
Polymer-Gold Nanocomposites as Intelligent Therapeutic Systems",
J. Biomed. Mater. Res.,
83A, 692-695 (2007).
- J.B.
Thomas, J. Tingsanchali,
A. Rosales, C.M. Creecy,
J. W. McGinity and N.A. Peppas, "Dynamics of Poly(ethylene glycol)-Tethered, pH
Responsive Biomaterials", Polymer, 48, 5042-5048 (2007).
- T.G. Farmer
Jr, T.F. Edgar and N.A.
Peppas, "The Future of Open
and Closed-Loop Insulin Delivery for Diabetes Mellitus", J. Pharm.
Pharmacol., 60, 1-13
(2008).
- O.Z. Fisher and
N.A. Peppas, "Quantifying Tight Junction Disruption
Caused by Biomimetic pH-Sensitive Hydrogel Drug Carriers", J. Drug
Delivery Sci. Techn.,
18, 47-50 (2008).
Extended List of Publications
|
