John Hazle
Deputy Chair (Interim)
Adjoint Professor |
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John Hazle
Deputy Chair (Interim), Adjoint Professor
Department of Biomedical Engineering
Research Interests
- Magnetic resonance imaging, image guided thermal therapy, experimental
animal imaging
My primary research interest is the development of novel MRI techniques
to monitor noninvasive or minimally invasive thermal therapies. MRI
can be performed to rapidly generate temperature maps of tissue heating,
making it possible to target and monitor thermal therapies in real
time. Our group is developing more robust (i.e., more sensitive and
faster) MRI techniques for temperature imaging, as well as new techniques
for estimating the extent of treatment. We are also exploring the
use of MR temperature imaging to monitor the effects of minimally
invasive therapies using interstitial and transurethral ultrasound
applicators and lasers in animal models of prostate and brain cancer. In
collaboration with Dr. Jonathan Ophir at The University of Texas-Houston
Health Science Center, we have shown that ultrasound elastography
can estimate changes in tissue mechanical properties associated with
thermal injury as a means of better defining the treatment volume.
Dynamic paramagnetic contrast-enhanced
MR techniques have been used to noninvasively evaluate the microvascular
status of tissues to differentiate between tumors and treatment-related
effects. In collaboration with Dr. Edward Jackson (this department),
fast spin-echo MRI perfusion imaging was developed at M. D. Anderson
and is being used clinically to differentiate between tumors and treatment-related
changes. The current analysis is based on an empiric model of contrast
material uptake. An animal-optimized 4.7 T MR system will soon be
available for use in experiments to expand our understanding of how
the microvasculature develops during tumor progression and the changes
that can be observed noninvasively during antiangiogenic therapy.
Selected Publications
- Hazle JD, Jackson EF, Schomer DF, Leeds NE. Dynamic imaging
of intracranial lesions using
fast spin-echo imaging: Differentiation of tumors and treatment
effects. J Magn Reson Imaging, 7:1084-1094,
1997
- Hazle JD, Stafford
RJ, Price RE. MR guided focused
ultrasound thermal therapy in
experimental animal models: Correlation of ablation volumes with
pathology in muscle and VX2 tumors. J
Magn Reson Imaging, 15(2): 185-194,
2002.
- Kallel F, Stafford RJ,
Price RE, Righetti R, Ophir J,
Hazle JD. The feasibility of
elastographic visualization of
HIFU-induced thermal lesions
in soft tissues. Ultrasound
Med Biol, 25: 641-647, 1999
- Stafford RJ, Hazle JD,
Glover GH. Monitoring of high-intensity
focused ultrasound-induced temperature
changes in vitro using an interleaved
spiral acquisition. Magn
Reson Med, 43: 909-912, 2000
- Hazle JD, Diederich CJ,
Kangasniemi M, Price RE, Olsson
LE, Stafford RJ, MRI guided thermal
therapy of transplanted transmissible
venereal tumors in the canine
prostate tumors with a directive,
transurethral ultrasound applicator. J Magn Reson Imag, 15(4): 409-417,
2002.
- Kangasniemi
M, Diederich CJ, Price RE, Olsson
LE, Stafford RJ, Schomer DJ,
Hazle JD. Multiplanar
temperature sensitive
MR imaging of cerebral tumor
treatments using an interstitial ultrasound applicator in a canine
model. J Magn Reson Imag, 16(5): 522-31, 2002.
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