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George Georgiou, Ph.D. Professor

George Georgiou, Ph.D.

Professor
Cockrell Family Regent’s Chair in Engineering #9

• Curriculum Vitae
• Department of Biomedical Engineering
  Institute for Cellular and Molecular Biology
  ENS 617A
  The University of Texas at Austin
  1 University Station, C0800
  Austin, Texas 78712-1084
  Phone: (512) 471-6975
  Fax: (512) 471-7963
  
• Lab Website

Research Focus

Biotechnology

Research Interests

Our group employs molecular biology and genetic approaches for the design and production of proteins with improved function and for the engineering of cellular physiology. Current research projects include:

1. Development of new technologies to aid protein engineering and drug discovery;
2. Engineering of therapeutic and diagnostic antibodies;
3. Engineering of novel enzymes;
4. The mechanism of oxidative protein folding in bacteria;
5. Protein secretion pathways in bacteria;
6. Regulation of RNA turnover;
7. Biologically templated nanomaterials

Selected publications

• Masip, L. Pan, J., Haldar, S., Penner-Hahn, J.A., Delisa, M.P., Georgiou, G., Bardwell, J.C.A. and J.F. Collet, "Engineering a de novo Pathway for the Formation of Protein Disulfide Bonds in Bacteria," Science 304:1185-190 (2004).
• Mao, C., Solis, D.J., Reiss, B.D., Kottmann, S.T., Sweeney, R.Z., Hayhurst, A., Georgiou G., Iverson, B.L. and A.M. Belcher, "Virus-Based Toolkit for the Directed Synthesis of Magnetic and Semiconducting Nanowires," Science 303:213-17 (2004).
• Kawarasaki, Y., Griswold, K.E., Selzer, T., Benkovic, S.J., Iverson, B.L. and G. Georgiou "Enhanced Crossover SCRATCHY: Construction and High-throughput Screening of a Combinatorial Library Containing Multiple Non-Homologous Crossovers," Nucleic Acid Res. 31:E126 (2003).
• Lee, K., Zhan X., Gao, J. Qiu, J., Feng, Y., Meganathan, R., Cohen, S.N. and G. Georgiou, "RraA: A Protein Inhibitor of RNase E activity that Globally Modulates RNA Abundance in E. coli," Cell 114:623-644(2003)
• Georgiou G. and L. Masip, "An Overoxidation Journey with a Return Ticket," Science 300: 592-594 (2003).
• Delisa, M. P., Tullman, D. and G. Georgiou,  "Folding Quality Control in the Export of Proteins via the Bacterial Twin Arginine Translocation Pathway" Proc. Natl. Acad. Sci. U.S.A. 100: 6115-20 (2003).
• Hayhurst, A., Happe, S., Mabry, R., Koch, Z., Iverson, B.L. and G. Georgiou, "Isolation and Expression of Recombinant Antibody Fragments to the Biological Warfare Pathogen Brucella melitensis" J. Immunol. Methods 276:185-196 (2003).
• Georgiou, G "How to Flip a (Redox) Switch" Cell 111: 607-610 (2002).
• Maynard, J.A., Leppla, S.H., Bratt, K., Patterson, J.L., Iverson, B.L. and G. Georgiou, "Protection Against Anthrax Toxin by Recombinant Antibody Fragments Correlates with Antigen Affinity", Nature Biotechnology 20:577-601 (2002).