Nicholas A. Peppas
Professor & Director of the Institute for Biomaterials, Drug Delivery and Regenerative Medicine
Cockrell Family Regents Chair in Engineering #6
Cellular and Biomolecular Engineering
Phone: (512) 471-6644
Office: BME 3.503C
Controlled drug delivery; Biomedical engineering; Biomaterials; Tissue engineering; Molecular modeling of protein structures in contact with biomaterials and tissues; Modeling of biomedical devices; Bionanotechnology; Molecular recognition processes; Polymer physics; Polymerization reaction engineering; Diffusion in polymers.
Our research contributions have been in several areas of drug delivery, biomaterials, biomolecular engineering, mass transfer, kinetics and reaction engineering, polymers and biomedical engineering. The multidisciplinary approach of thiis research in biomolecular engineering blends modern molecular and cellular biology with engineering to generate next-generation systems and devices, including bioMEMS with enhanced applicability, reliability, functionality, and longevity. The fundamental studies of his group have provided valuable results on biomaterials design and development. Our group is known for our work on the preparation, characterization and evaluation of the behavior of compatible, cross linked polymers known as hydrogels, which have been used as biocompatible materials and in controlled release devices, especially in controlled delivery of drugs, peptides and proteins, development of novel biomaterials, biomedical transport phenomena, and biointerfacial problems. This work has led to a series of novel controlled release systems known as swelling controlled release systems, a series of pH-sensitive devices for drug delivery and a wide range of bio- and mucoadhesive systems. They include novel systems for insulin delivery to treat Type 1 diabetic patients, calcitonin delivery for osteoporosis treatment, growth hormone delivery, delivery of siRNA for treatment of Crohn's disease, ulcerative colitis and celiac disease, treatment of hemophilia by oral Factor IX delivery, new systems for interferon beta delivery for multiple sclerosis treatment, etc. Other biomedical work of his group had dealt with understanding of transport of biological compounds in tissues, analysis of polymer/tissue interactions, understanding of the behavior of biomembranes, and intelligent, recognitive systems for protein delivery.
- N. Annabi, A. Tamayol, J.A. Uquillas, M. Akbari, L. Bertassoni, C. Cha, G. Camci-Unal, M. Dokmeci, N.A. Peppas and A. Khademhosseini, Emerging Frontiers in Rational Design and Application of Hydrogels in Regenerative Medicine, Adv. Materials, 26, 85-124 (2014).
- A. K. Gaharwar, N. A. Peppas, A Khademhosseini, Nanocomposite Hydrogels for Biomedical Applications, Biotechnology & Bioengineering, 111, 441-453 (2014)
- J.M. Knipe, F. Chen, N.A. Peppas, Multi-responsive polyanionic microgels with inverse pH responsive behavior by encapsulation of polycationic nano gels, J Appl Polym Sci, 131, 40098 (2014).
- L. A. Sharpe, A. Daily, S. Horava and N. A. Peppas, Therapeutic applications of hydrogels in oral drug delivery. Exp. Opinion on Drug Delivery, 11, 901-915 (2014).
- D. C. Forbes and N. A. Peppas, Polycationic Nanoparticles for siRNA Delivery: Comparing ARGET ATRP and UV-initiated Formulations, ACS Nano, 8, 2908-2917 (2014).
- M. C. Koetting and N. A. Peppas, pH-Responsive poly(itaconic acid-co-N-vinylpyrrolidone) hydrogels with reduced ionic strength loading solutions offer improved oral delivery potential for high isoelectric point-exhibiting therapeutic proteins, Intern J Pharmac, 471, 83-91 (2014).
- H. Culver, A. Daily, A. Khademhosseini and N.A. Peppas, Intelligent recognitive systems in nanomedicine, Current Opinions in Chemical Engineering, 4, 105-113 (2014).
- M Durán-Lobato, B Carrillo-Conde, Y Khairandish, NA Peppas, Surface-modified P(HEMA-co-MAA) Nanogel Carriers for Oral Vaccine Delivery: Design, Characterization, and Targeting Evaluation, Biomacromolecules, 15, 2725-2743 (2014).
- D. C. Forbes and N. A. Peppas, Polymeric Nanocarriers for siRNA Delivery to Murine Macrophages, Macromol Biosci., 14, 1096-1105 (2014).
- NA Peppas, B Narasimhan, Mathematical models in drug delivery: How modeling has shaped the way we design new drug delivery systems, J. Controlled Release, 190, 75-81 (2014).
- A.K. Gaharwar, N.A. Peppas and A. Khademhosseini, Nanocomposite Hydrogels for Biomedical Applications, Biotechnology & Bioengineering, 111, 441-453 (2014)
- N Annabi, A Tamayol, SR Shin, AM Ghaemmaghami, NA Peppas, A. Khademhosseini, Surgical Materials: Current Challenges and Nano-enabled Solutions, Nano Today, 9, 574-589 (2014).
- A Singh, NA Peppas, Hydrogels as scaffolds for immunomodulation, Adv. Mater., Hydrogels as scaffolds for immunomodulation, Adv. Mater., 26, 6530-6541, (2014).
- J. M. Knipe and N.A. Peppas, Multi-responsive Hydrogels for Drug Delivery and Tissue Engineering Applications, Regenerative Biomaterials, 1, 57-65 (2014).
- N.A. Peppas, M. Caldorera-Moore and S.D. Steichen, Historical Survey of Drug Delivery Devices, in "Drug-Device Combinations for Chronic Diseases," R. Siegel and S P Lyu, eds., 39-65, Drug-Device Combinations for Chronic Diseases, Wiley, New York, NY (2015).
- D.S. Spencer, A.S. Puranik, N.A. Peppas, Intelligent Nanoparticles for Advanced Drug Delivery in Cancer Treatment, Curr. Opin Chem. Engineer., 7, 84-92 (2015).
- S.R. Marek, M.L. Gran, N.A. Peppas, M. Caldorera-Moore, Intelligent, Responsive and Theranostic Hydrogel Systems for Controlled Delivery of Therapeutics, in HJ Schneider, ed, Chemoresponsive Materials: Stimullation by Chemical and Biological Signals, RSC, London, 2015.
- BV Slaughter, AT Blanchard, KF Maass, NA Peppas, Dynamic swelling behavior of interpenetrating polymer networks in response to temperature and pH, J Appl Polym Sci, 132, 42076 (2015)
- M.C. Koetting, J.T. Peters, S.D. Steichen, NA Peppas, Stimulus-responsive Hydrogels: Theory, modern advances and applications, Mat. Sci. Engin. R: Reports, 93, 1-49 (2015).
- J. M. Knipe, F. Chen, N. A Peppas, Enzymatic Biodegradation of Hydrogels for Protein Delivery Targeted to the Small Intestine, Biomacromolecules, 16, 962-972 (2015).
- C. A. Reinhart-King, C. E. Schmidt and N.A.Peppas, The 2015 Young Innovators of Cellular and Molecular Bioengineering, Cell. Molec. Engn., 6, 305-306 (2015),
- B. Carillo-Conde, E. Brewer, A.M. Lowman and N.A. Peppas, Complexation Hydrogel Carriers as Oral Delivery Vehicles of Therapeutic Antibodies: An in-vitro and Ex-vivo Evaluation of Antibody Stability and Bioactivity, Ind. Engn. Chem. Res., (published on line, DOI: 10.1021/acs.iecr.5b01193).
- M Caldorera-Moore, G Fletcher, K. Maas, R. Hegab and N.A. Peppas, Hybrid Responsive Hydrogel Carriers for Oral Delivery of Low Molecular Weight Therapeutic Agents , J. Drug Deliv. Sci. Techn., (published on line, doi:10.1016/j.jddst.2015.07.023.