Laboratory for Cellular and Macromolecular Engineering

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Welcome to The Laboratory for Cellular and Macromolecular Engineering

The behavior of cells and tissues and that of the whole organism is a unique combination of their genetic makeup and their microenvironment. The ability to effectively transfer genes into humans provides unique possibilities for the treatment of various diseases. Efficient expression of antigenic proteins in-vivo following gene delivery, can “train” our immune system to fight against incurable cancers and deadly infectious diseases. On the other hand rational manipulation of the microenvironment of stem and progenitor cells provides us with the opportunity to precisely control and manipulate their differentiation and develop unique approaches for cell-based therapeutics.

The overall goal of our research endeavor is the development of new biomaterial-based strategies for gene/drug delivery and stem cell engineering. Towards this, my laboratory focuses on three major directions: (a) design and development of novel delivery systems for nucleic-acid based immunotherapy and cancer chemotherapy (b) engineering complex microenvironments to study and manipulate stem cells and understand their behavior in biomimetic, three-dimensional conditions and (c) developing novel engineering tools and high throughput methods to generate functional T cells and Dendritic cells from stem cells.

Krishnendu Roy, Ph.D.
Associate Professor and Graduate Advisor
General Dynamics Faculty Fellow
The Department of Biomedical Engineering
The University of Texas at Austin
1 University Station, C0800
Austin, TX 78712
(512) 232-3477

News & Events:

Congratulations to Dr. Bilal Ghosn - recent graduate of the Roy Lab!

Press Release: Dr. Roy Develops Novel Vaccine Delivery System. details

Dr. Roy elected to the American Institute for Medical and Biological Engineering (AIMBE). details

New paper by Ankur, et al, in Molecular Therapy. details

Welcome to new Roy Lab member - Nathalie!

Ankur receives the STAR award at the Society for Biomaterials 2008 Symposium, Atlanta, Georgia. details

Ankur receives the 2008 Graduate Student Professional Development Award by Office of The Vice Provost and Dean of Graduate Studies, The University of Texas at Austin.

Julie receives NDSEG Fellowship.

Welcome to new Roy Lab members - Julie and Irina!

Roy Lab moves to 5th floor of new BME Building! details

Michelle receives NSF GRFP Honorable Mention.

Congratulations to Dr. Sabia Taqvi, Dr. Gazell Mapili, and Dr. Cristal Glangchai - recent graduates of the Roy Lab.

Prinda receives NSF Graduate Research Fellowship.

Eileen receives NDSEG Fellowship.

New paper by Eileen, et al, in Advanced Drug Delivery reviews. details

New paper by Bilal in Current topics in Medicinal Chemistry. details

New paper by Cristal and Mary in Journal of Controlled release. details

Dr. Roy receives 2007 Young Investigator Award from the Society for Biomaterials. read more

Dr. Roy receives 2007 Young Investigator Award from the Houston Society for Engineering in Medicine and Biology.

Dr. Roy receives NSF CAREER award. read more

Dr. Roy receives Global Indus Technovators award. read more

Dr. Roy appointed to editorial board of the Journal of Controlled Release. read more

See news archives for older news