Roles of Immuno-Mechanics in the Vasculature

Thursday, March 24, 2022
3:30 pm - 5:00 pm

Location: BME 3.204

Jay D. Humphrey, PhD
John C. Malone Professor of Biomedical Engineering
Chair, Department of Biomedical Engineering
School of Engineering & Applied Science
Yale University


 All cells within the vascular wall are exquisitely sensitive to changes in mechanical loading, often leading to changes in gene expression that affect the composition and organization of the extracellular matrix. This matrix, in turn, is largely responsible for both normal and abnormal vascular resilience, compliance, and strength. It is becoming increasingly clear that immunobiological processes can either promote or prevent the mechanobiological processes that enable appropriate vascular properties. In this talk, we will explore new approaches to measure and model aspects of immuno-mechanics that are fundamental to many vascular conditions. Data will be drawn from diverse mouse models; simulations will stem from novel computational simulations of vascular growth and remodeling. 

Presenter Information