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General Course Information:
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BME 360 Engineering Applications of Immunology and Disease
Pathology
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Instructor Information:
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Sharon
Thomsen, M.D.
Lecturer
Office
Address: ENS 610
Telephone
Number: 232-5910
Fax Number:
471-0616
Email: thomsen@ece.utexas.edu
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2002-2003 Catalog Data
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Textbooks: Cotran, R, V. Kumar and T.
Collins. Robbins Pathologic Basis
of Disease. 6th
edition. W. B. Saunders Co. Philadelphia. 1999
Additional References: Relevant handouts on
newest technologies and
information on pathologenesis and pathologic mechanisms.
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Coordinator
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Sharon Thomsen, M.D.
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Goals
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Gain a general understanding of human immunology
Understand the basic pathologic mechanisms of the more prevalent human
diseases.
Understand how these mechanism interacting with the functional anatomy of
different tissues can be used to guide engineering development of
diagnostic and/or therapeutic methods and instrumentation.
Understand the dynamics of disease pathologenesis, development and
resolution.
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Knowledge, Abilities, and Skills Students Should Have
Entering This Course
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Required course prerequisites: Bio 211, 212 and
205. BME 365R and BME 365 S.
The students should have a general
background knowledge in biomedical engineering.
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Knowledge, Abilities, and Skills Students Should Gain From
This Course
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The students will have gained a general understanding of the
mechanisms and dynamics of disease and the impact of these on the
development of accurate and specific diagnostic and therapeutic methods
and instrument.
The students will have gained the abilities to
recognize that basic pathologic mechanisms will be modified by the
specific functional anatomy of the involved tissue/organ.
The students will become comfortable with biologic variation of normal
and diseased tissues and organs.
The students will become familiar with and critical of library searches
and literature specific to medicine, anatomy, physiology and pathology.
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Impact on Subsequent Courses in Curriculum
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The knowledge obtained will add practical perspective to the
students productive participation in the BME 371 Capstone BME Design
Projects and BME senior projects.
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Criteria 2000 Outcomes Achieved
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a. Biology
b. Design
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Program Criteria Outcomes Achieved
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a. An ability to
apply knowledge of mathematics, science, and engineering.
b. An ability to design and conduct experiments, as well as to
analyze and interpret data.
c. An ability to design a system, component, or process to
meet desired needs.
g. An ability to communicate effectively.
h. The broad education necessary to understand the impact of
engineering solutions in a global/societal context.
i. A recognition of the need for and an ability to engage in
lifelong learning.
j. A knowledge of contemporary issues.
k. An ability to use the techniques, skills, and modern
engineering tools necessary for engineering practice.
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Professionalism Topics
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Impact of disease on humans.
Limitations of mathematical and physical experimental models for
accurate instrument applications in living animals and humans.
Need to review the literature to gain
background knowledge about the disease.
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Topics (referenced to Criteria 2000 and program criteria
outcomes)
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Introduction and
overview of immunology. Illustrative Case Analysis:
1. Antibody formation after vaccination
2. immunologic mechanisms of transplant rejection:
Pathogenesis,
development and resolution of the following basic pathologic processes:
1. Hemorrhage, and thrombosis. Illustrative Case
Analysis: Coronary Atherosclerosis
2. Acute and chronic inflammation. Illustrative Case
Analysis: Bacterial cutaneous abscess (Acne) and Chronic viral
hepatitis
3. Necrosis and Tissue Death: Illustrative Case Analysis:
Myocardial Infarction.
4. Wound healing. Illustrative Case Analysis: Resolution of
Interstitial Thermal Tissue Coagulation
5. Neoplasia: Including pathogenesis, genetics, disease progression
and pathology
a. Illustrative Case
Analysis: Colon Carcinoma
Pathology of Being a Tube:
1. Pathologies and Diseases based on tubular structure of the
organs.
2. Illustrative Organ Systems: Cardiovascular, Gastrointestinal,
Urinary and Respiratory Systems
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