|
September 16
(Please note: DIFFERENT room,
ACE 2.402)
Omar
Ghattas, PhD
Director, Ultrascale Simulation Lab
Professor, Department of Biomedical Engineering
Professor, Department of Civil & Environmental
Engineering
Carnegie Mellon University
Image-based Deformable Registration for
Patient-Specific Surgical Simulation
Direct generation of high-quality
patient-specific physical models for surgical simulation
requires image segmentation, surface reconstruction, mesh
generation, and model construction, and is difficult to
automate fully for complex anatomic geometries. We consider
simulation of orthopedic surgical procedures based on CT
images. We overcome the problem of generating patient-specific
models by generating several high-quality template meshes
offline. Then, for a given patient's CT image, we employ
image-based registration techniques to elastically deform the
template mesh so that it conforms to the patient's geometry.
Examples demonstrate that direct-from-CT finite element models
can be generated rapidly and robustly.
This seminar
will be video-conferenced to the Texas Medical Center. It can be
viewed in Houston at the M. D. Anderson Houston Main Building,
HMB 9.116, 1100 Holcombe Blvd.
|
|
September 23
Bernhard
Palsson, PhD
Professor, Department of Bioengineering
University of California at San Diego
Bringing Genomes
To Life: The Role of Genome-Scale In Silico Models
|
|
October 7
Charles Friedman, PhD
Professor of Medicine, Director of the Center for Biomedical
Informatics,
and Director of the Medical Informatics Training
Program
University of Pittsburgh
A
Fundamental Theorem of Biomedical Informatics OR What Is
Informatics Anyway?
|
|
October 21
Robert
Murphy, PhD
Professor of Biological Sciences and Biomedical Engineering
Carnegie Mellon University
Location Proteomics: Protein Tagging, High-Throughput
Fluorescence Microscopy and Machine Learning
|
|
October 28
Matthew O'Donnell, PhD
Professor and Chair,
Biomedical Engineering
Professor,
Electrical Engineering & Computer Science
Jerry W. and Carol L. Levin Professor of
Engineering
University of Michigan
Can Vulnerable
Plaques Really Be Detected?
|
|
November 18
Kevin
Healy, PhD
Associate Professor,
Departments of Bioengineering and Materials Science &
Engineering
University of California at Berkeley
Challenges in Designing Materials that Dictate Tissue
Regeneration
A central limitation in the performance of
materials used in the medical device industry is that they lack
the ability to integrate with biological systems through either
a molecular or cellular pathway. This inability to interact
with biological systems has relegated biomaterials to a passive
role dictated by the constituents of a particular environment,
leading to unfavorable outcomes and device failure in some
cases. New classes of materials are being designed to overcome
this limitation by actively directing the formation of organ
specific tissue in contact with the material. Toward this goal,
we have designed and synthesized model biomimetic materials that
can be used to test hypotheses regarding cell-materials
interactions. This lecture will first emphasize
surface engineering strategies for modification of medical
devices and subsequently will address design rules to guide the
synthesis and fabrication of artificial extracellular matrices
for in situ tissue regeneration. The universal nature of
biomimetic modification strategies and characterization
modalities will be addressed in the context of these examples.
This research was supported by grants from the
NIH R01 AR43187 and R01 AR47304.
|
|
|
