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Translational biomedical engineering plays an important role in assimilating the advancement of device engineering towards developing innovative diagnosis, treatment and prevention of important human diseases at genetic, molecular and cellular levels. The micro-nano scale tools for cell manipulation, dynamic culturing and in vivo microscopy contribute to the continuity of investigations across the biological hierarchy of multiple scales, culminating in the understanding of whole body functions in health and disease. Nano-Micro, Info, and Bio are integrative components of our research, in which engineering expertise in micro-electro-mechanical systems (MEMS) and nanotechnologies, photonics, microfluidics and informatics is synergized to facilitate biomedical studies and point-of-care (POC) diagnostics for global health initiatives, and to obtain a better understanding of the fundamental problems in life science. This in turn benefits the advancement of engineering research.
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Microelectronics Research Center Tel: (512) 475-6872 Research Administration: |
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Our research focuses on the biomedical applications of photonic Microsystems (MEMS/NEMS), semiconductor chips and nanotechnologies, in particular, on imaging, sensing and regulating cellular processes critical to development and disease. The actively pursued areas are: (1) Nano-microfabricated photonic sensors for characterizing the cell mechanics, microscanners for molecular imaging and microscopy towards miniaturized endoscopic pre-cancer detection and diagnosis, and near-field nano-patterning of biomaterials. (2) Hybrid microfluidic-on-silicon instruments for in-vivo cell and embryo manipulation, culturing and analysis; in particular, microinjections, ultrasonic cellular-scale surgical tools, self-assembly and high-speed particle sorting for studying cellular interactions and embryo development network. (3) Multi-scale simulation of fundamental force, flow, energy processes involved in cell-substrate interactions. Recent work includes theoretical and experimental studies on the energy dissipation process associated with fluidic self-assembly for both soft biological samples and silicon chips. 
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| Copyright © 2005 John X.J. Zhang, Ph.D Site design: Academic Web Pages |