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Michael A. Choma, MD, PhD

Assistant Professor

Departments of Radiology & Biomedical Imaging, Pediatrics, Biomedical Engineering, and Applied Physics

Yale University

Attending Physician, Pediatric Primary Care Center,

Yale-New Haven Hospital

 I will discuss my top-down approach to developing new optical imaging technologies to study pediatric disease. These diseases include respiratory disease and congenital heart disease. My top-down approach focuses on (1) addressing critical technological gaps that limit our ability to study specific aspects of pediatric disease pathophysiology and (2) maximizing information extraction from current-generation imaging technologies in a disease-specific context. By addressing critical gaps, my lab has developed key enabling technologies for the high-speed, highly-parallelized imaging of microscale flows and motions. By focusing on information extraction, we have developed novel quantitative metrics to quantify pathological microscale physiological performance. These quantitative metrics are particularly useful in studying the role that cilia-driven fluid flow plays in both rare and common pediatric respiratory diseases.