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Project Description:
In addition to
"building-up" synthetic materials, we have ongoing research in which we are
exploring the use of processed natural tissues for use in biomedical
applications.
We have worked in
collaboration with Sulzer Biologics to explore the use of
PhotoFix vascular tissue that has been treated using a dye-mediated
photooxidation process. These natural vascular biomaterials can be used in
various cardiovascular applications, including vascular grafts. In addition to
PhotoFix natural tissue, we are also developing our own acelluar tissues using
chemical decellularization techniques. In particular, we are focusing on the
creation of acellular nerve grafts that retain the structural properties of the
nerve, but are lacking the immunogenic cellular components. Finally, we are
developing natural-based hydrogels from hyaluronan for use in wound healing
applications. Hyaluronan is a natural sugar molecule that is found in the body
in large concentrations during both embryogenesis and wound healing; hyaluronan
has been shown to stimulate angiogenesis or new blood vessel growth as it is
degraded.
The figure above is a fluorescence
microscope image of a cross-section of a section of fresh nerve tissue that has
been stained for axons (red) and the Schwann cells that make up myelin (green).
The goal in creating an acellular tissue is to remove the cellular components
(i.e., the axons and the Schwann cells).
Recent Publications:
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Leach, J.B., C.E. Schmidt (2005).
Characterization of protein release from photocrosslinkable hyaluronic
acid-polyethylene glycol hydrogels. Biomaterials. 26(2):125-135.
*Download PDF File*
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Leach,
J.B., C.E. Schmidt (2004). Photocrosslinkable hyaluronic acid hydrogels for
tissue engineering. Materials Research
Society Symposium Proceedings: "Architecture and Application of Biomaterials
and Biomolecular Materials", A.E. Barron, K.
Harm-Anton, T.J. Deming, eds,
Volume EXS-1, pp. 33-55.
*Download PDF File*
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Carnagey, J., D. Hern-Anderson, J.
Ranieri, C.E. Schmidt (2003). Rapid endothelialization of PhotoFix natural
biomaterial vascular grafts. Journal of Biomedical Materials Research
Part B: Applied Biomaterials. 65B (1):171-179.*Download
PDF File*
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Dixit, P., D. Hern-Anderson, J. Ranieri, C.E. Schmidt (2001). Vascular graft endothelialization: comparative analysis of canine and human endothelial cell migration on natural biomaterials. J. Biomed. Mater. Res. 56:545-555.*Download PDF File*
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Schmidt, C.E., J.M. Baier (2000). Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering. Biomaterials. 21(22):2215-2231.*Download PDF File*
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