Stanislav Emelianov, Ph.D.
Assistant Professor |
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Stanislav Emelianov, Ph.D.
Assistant Professor
- Department of Biomedical Engineering
Institute for Cellular and Molecular Biology
The University of Texas at Austin
1 University Station
Austin, Texas 78712-0238
- Lab Website
Research Focus
Medical imaging for therapeutics and diagnostic applications, ultrasound microscopy, elasticity imaging, opto-acoustical imaging, acousto-mechanical imaging, radiation pressure imaging.
Research Interests
The research at Panscopic Imaging Laboratory is focused on developing macro- and microscopic (i.e., panscopic) imaging methods for fundamental biomedical research, biomedical applications, and clinical practice. Among many ambitious research areas in biomedical imaging ranging from full body or organ visualization to molecular and nanoscale imaging, several are highlighted below:
Ultrasound Microscopy: Imaging of living tissue at microscopic resolution, including cellular and molecular levels, is critically desired in biomedical engineering and other fields. In medicine, microscopic imaging can help differentiate normal and pathologically transformed tissue otherwise only available from biopsy and histology. In experimental biology, microscopy can be used in tissue engineering, cellular and molecular biology, neurobiology, and physiology. It also offers a great tool to study small animal models in-vivo. Compared to other microscopy imaging techniques, high-frequency ultrasound biomicroscopy has unique advantages for many biomedical applications. First, an ultrasound microscope operates in-vivo or on large samples of living tissue with a resolution approaching cellular level. Ultrasound microscopy is a non-invasive tool and can be used in conjunction with existing invasive procedures. Second, a large field of view and 3-D imaging either eliminates or simplifies sample preparation. Finally, unique novel imaging methods offer quantitative imaging of tissue parameters (e.g. elasticity, structural integrity, flow velocity and volume, etc.) at microscopic resolution.
Radiation Pressure Imaging: The core of radiation pressure imaging is remote mechanical excitation of tissue using radiation force of an amplitude-modulated beam of focused ultrasound. The response of the tissue to remote excitation is subsequently detected and analyzed to reveal structural and mechanical properties of the tissue.
Ultrasound and MRI based Elasticity Imaging: The underlying hypothesis in elasticity imaging is that changes in soft tissue elasticity (or hardness) are often related to some abnormal, pathological processes. Because of this, palpation, even limited to abnormalities located relatively close to the skin surface, is still a widely used diagnostic technique. The fundamental goal of elasticity imaging is to develop surrogate, remote palpation, thus expanding palpation's limited range to include deep lying lesions. Unfortunately, no conventional modality, including ultrasound, nuclear magnetic resonance (MRI) or computed tomography (CT), can directly provide information about tissue elasticity. However, using modern medical imaging devices to precisely measure internal tissue motion in response to externally applied force/deformation, it is possible to estimate and image elastic properties of internal organs. Over the years, elasticity imaging has emerged as a potentially new diagnostic modality capable of providing information about the mechanical properties of internal organs. Elasticity imaging was primarily developed for two imaging platforms - ultrasound and MRI, since the signal phase can be exploited to sensitively track internal tissue motion while applicability of other imaging systems such as mammography and computed tomography for elasticity imaging was also demonstrated. Several potential applications of elasticity imaging were identified, such as early detection of renal transplant rejection, differentiation of vulnerable plaques in coronary artery, prostate carcinoma detection, breast cancer imaging, etc.
Selected Publications
- N.A. Cohn, S.Y. Emelianov, M.A. Lubinski, and M. O'Donnell, "An elasticity microscope. Part I: Methods, and. Part II: Experimental results," IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 44, pp. 1304-1331 (1997).
- A.P. Sarvazyan, O.V. Rudenko, S.D. Swanson, J.B. Fowlkes, and S.Y. Emelianov, "Shear wave elasticity imaging - a new ultrasonic technology of medical diagnostic," Ultrasound in Medicine and Biology, 24, pp. 1419-1436 (1998).
- D.D. Steele, T.L. Chenevert, A.R. Skovoroda, and S.Y. Emelianov, "Three-dimensional static displacement, stimulated echo NMR elasticity imaging," Physics in Medicine and Biology, 45, pp. 1633-1648 (2000).
- K.W. Hollman, S.Y. Emelianov, J.H. Neiss, G. Jotyan, G.J.R. Spooner, T. Juhasz, R.M. Kurtz and M. O'Donnell, "Strain imaging of corneal tissue with an ultrasound elasticity microscope," Cornea, 21(1), pp. 68-73 (2002).
- S.Y. Emelianov, X. Chen, M. O'Donnell, B. Knipp, D. Myers, T.W. Wakefield, and J.M. Rubin, "Triplex ultrasound: Elasticity imaging to age deep venous thrombosis," Ultrasound in Medicine and Biology, 28, pp. 757-767 (2002)
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