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Andrew Dunn Assistant Professor

Andrew Dunn

Assistant Professor

• Department of Biomedical Engineering
  Institute for Cellular and Molecular Biology
  The University of Texas at Austin
  1 University Station
  Austin, Texas 78712-0238
  
• Lab Website

Research Interests

Dr Dunn's research is focused on developing novel optical imaging techniques for imaging brain function. We seek to integrate innovative photonics and computational techniques and to apply them to research questions in areas such as stroke, migraine, functional mapping during neurosurgery, and Alzheimers disease. In addition we are developing imaging techniques that aid in furthering our understanding of basic neurophysiological mechanisms. One of the techniques we have developed is laser speckle contrast imaging of blood flow, which we have used to dynamically image the cerebral blood flow changes during stroke, migraine and normal brain activation. We collaborate closely with neuroscientists, neurologists and neurosurgeons in the application of these imaging techniques to various problems related to brain function.

Students interested in optical and molecular imaging or applications in neuroscience are encouraged to contact Dr Dunn.

Selected Publications

• Yuan S, Boas DA, Dunn AK, "Determination of optimal exposure time for imaging of blood flow changes with laser speckle contrast imaging", Applied Optics, in press 2005.
• Devor A, Ulbert I, Dunn AK, Narayanan S, Jones SR, Andermann ML, Boas DA, Dale AM, "Coupling of the Cortical Hemodynamic Response to Cortical and Thalamic Neuronal Activity", Proceedings of the National Academy of Sciences, in press 2005.
• Hillman EM, Boas DA, Dale AM, Dunn AK., "Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media.", Optics Letters. 2004, 15;29(14):1650-2.
• Ayata C, Dunn AK, Gursoy-OZdemir Y, Huang Z, Boas DA, Moskowitz MA., "Laser speckle flowmetry for the study of cerebrovascular physiology in normal and ischemic mouse cortex.", J Cereb Blood Flow Metab. 2004;24(7):744-55.
• Devor A, Dunn AK, Andermann ML, Ulbert I, Boas DA, Dale AM., "Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex.", Neuron. 2003 17;39(2):353-9.
• Dunn AK, Devor A, Bolay H, Andermann ML, Moskowitz MA, Dale AM, Boas DA., "Simultaneous Imaging of Total Cerebral Hemoglobin Concentration, Oxygenation and Blood Flow During Functional Activation", Optics Letters 2003; 28(1):28-30.
• Bolay H, Reuter U, Dunn AK, Huang Z, Boas DA, Moskowitz MA., "Intrinsic Brain Activity Triggers Trigeminal Meningeal Afferents in a Migraine Model", Nature Medicine, vol 8, pp 136-142 (2002).
• Dunn AK, Bolay H, Moskowitz MA, Boas DA., "Dynamic Imaging of Cerebral Blood Flow Using Laser Speckle", Journal of Cerebral Blood Flow and Metabolism vol 21 pp 195-201, 2001.
• Dunn AK, Boas DA, "Transport Based Image Reconstruction in Turbid Media with Small Source-Detector Separations," Optics Letters , vol 25, pp 1777-1779 (2001).