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Charles Cox, M.D.

Charles Cox, M.D.
Adjoint Professor

Charles Cox, M.D.

Adjoint Professor
Department of Biomedical Engineering

Education

Undergraduate Education

  • 1980-1984   University of Texas at Austin BA

Graduate Education

  • 1984-1988   University of Texas Medical Branch at Galveston MD

Postgraduate Training

  • Internship in Surgery:

    • 1988-1989   University of Texas Health Science Center at Houston
  • Residency in Surgery:

    • 1989-1990   University of Texas Health Science Center at Houston
    • 1992-1993   University of Texas Health Science Center at Houston
    • 1993-1994   University of Texas Health Science Center at Houston
  • Fellowship:

    • 1990-1992   NIH Research Fellow in Trauma and Burns
                          Shriner’s Burns Institute, University of Texas Medical Branch
    • 1994-1996   Pediatric Surgery, University of Michigan
    • 1996-1997   Surgical Critical Care, University of Texas-Houston

Publications

  1. Cox CS, James E, McClellan DG, Townsend CM, Thompson JC: Calmodulin antagonist trifluoperazine inhibits growth and survival of pancreatic cancer in vitro. Dig Dis Sci 1986; 31(10):1186. (Poster presentation)
  2. Cox CS, Zwischenberger JB, Traber LD, Traber DL, Herndon DN: Application of an intravenous mechanical blood oxygen/carbon dioxide exchange device (IVOX) for smoke inhalation injury in an ovine model. Cardiovascular Science and Technology: Basic and Applied, II 1:391, 1990.
  3. Wang CZ, Cox CS, Barrow RE, Herndon DN. Detergent induced change in pulmonary microvascular permeability. FASEB J 5:A769, 1991.
  4. Fleming RYD, Cox CS, Gore D, Honeycutt DA, Jahoor F, Wolfe RR, Herndon DN. Effect of propranolol on glucose uptake in hypermetabolic burned patients. Proc Am Burn Assoc, 124:125, 1992.
  5. Cox CS, Fleming RYD, Zwischenberger JB, Myers T., Kurusz M, Alison WE, Herndon DN. Ileal mucosal hypoperfusion during cardiopulmonary bypass. Crit Care Med 20:S64, 1992. (Poster presentation)
  6. Cox CS, Zwischenberger JB, Traber DL, Traber LD, Herndon, DN. Intravascular oxygenation/CO2 removal allows reduction of mechanical ventilation support in an ovine model of acute lung injury. Crit Care Med 20:S60, 1992. (Poster presentation)
  7. Cox CS, Zwischenberger JB, Graves D, Raymond G. Mortality from severe ARDS remains unchanged. Am Rev Resp Dis 145:A83, 1992. (Poster presentation)
  8. Cox CS, Zwischenberger JB, Graves D, Cardenas, V. Permissive hypercapnia with IVOX: A ventilation technique to reduce barotrauma. ASAIO Abstracts 21:65, 1992. (Poster presentation)
  9. Cox CS, Traber DL, Gasser H, Redl H, Schlag G, Herndon DN. Interleukin 6 levels in burned patients: Effect of inhalation injury. FASEB J 6:A2042, 1992. (Poster presentation)
  10. Cox CS, Zwischenberger JB, Traber DL, Traber LD, Haque AK, Herndon DN. Heparin improves oxygenation and minimizes barotrauma after severe smoke inhalation in an ovine model. Proc Am Burn Assoc 124:20, 1992. (Oral presentation)
  11. Cox CS, Zwischenberger JB, Traber LD, Traber DL, Herndon DN. Beneficial effects of heparin treatment of smoke inhalation injury not due to reduced oxygen free radical activity. Am Rev Resp Dis 145:A80, 1992. (Poster presentation)
  12. Zeigler ST, Cox CS, Meyer J, Traber DL, Herndon DN. The role of nitric oxide in the pulmonary pathophysiology of burn/sepsis. Am Rev Resp Dis A45:A313, 1992.
  13. Zwischenberger JB, Cox CS, Graves DF. Initial clinical experience with an intravascular oxygenator and carbon dioxide removal device (IVOX). Thorac Cardiovasc Surg 40:104, 1992.
  14. Meyer J, Cox CS, Traber DL, Nakazawa H, Herndon DN. Cardiopulmonary effects of heparin in endotoxemia. Circ Shock 37:40, 1992.
  15. Meyer J, Kramer GC, Cox CS, Traber DL, Nakazawa H, Herndon DN. Continuous small volume resuscitation with hypertonic saline/dextran solution improves survival in experimental sepsis. Circ Shock 39:12.49, 1993.
  16. Cox CS, Zwischenberger JB, Fleming RYD, Myers T, Kurusz M, Herndon DN, Kramer GC. Hypertonic saline-dextran does not improve regional perfusion in a porcine model of cardiopulmonary bypass. Proc Intl Conf on Hypertonic Resuscitation 5:4, 1992. (Oral presentation).
  17. Cox CS, Biondo N, Traber LD, Lentz CW, Herndon DN, Traber DL. Effects of superoxide dismutase (SOD) on pulmonary microvascular response to endotoxin. Proc Intl Endotoxin Society. 2:245, 1992. (Poster presentation)
  18. McDaniel LB, Cox CS, Zwischenberger JB, Kurusz M, Kramer GC. Effects of hypertonic saline dextran on intracranial pressure and brain water during CPB. Anesthesiology 77:A661, 1992.
  19. Nguyen TT, Herndon DN, Cox CS, Biondo N, Traber LD, Bush PE, Traber DL. Effects of MnSOD on lung fluid balance after smoke inhalation injury. Proc Am Burn Assoc 75:31, 1993.
  20. Nguyen TT, Cox CS, Fleming RYD, Traber DL, Gasser H, Redl H, Schlag G, Herndon DN. Free radical activity and loss of plasma antioxidants, Vitamin E, and sulfhydryl groups in burned patients. Proc Am Burn Assoc 75:146, 1993.
  21. Nguyen TT, Cox CS, Matheis E, Bush P, Traber DL, Herndon DN, Bidani A, Zwischenberger JB. Marked enhancement of carbon dioxide removal by second generation IVOX. ASAIO Abstracts, 1993.
  22. Nguyen TT, Cox CS, Tzounakis A, Bush P, Traber DL, Herndon DN, Bidani A, Zwischenberger JB. Carotid blood flow during permissive hypercapnia in an ovine model. Crit Care Med 21:S190, 1993.
  23. Zwischenberger JB, Nguyen T, Upp JR, Bush P, Cox CS, Delosh T., Broemling L. Complications of neonatal extracorporeal membrane oxygenation (ECMO): Experience from the Extracorporeal Life Support Organization. Proc Am Assoc Thorac Surg. (In Press)
  24. Nguyen TT, Zwischenberger JB, Cox CS, Bush P, Matheis E, Bidani A, Traber DL, Herndon DN. IVOX with permissive hypercapnia: A new management technique in an ovine smoke inhalation injury model. Proc Assoc Academic Surgery 27:136, 1993.
  25. Meyer J, Stothert JC, Pollard V, Potter R, Cox CS, Traber LD, Traber DL. Nitric oxide synthesis inhibition in ovine endotoxemia: Effects on brain blood flow. Anesth Analg 76:S264, 1993
  26. Reickert CA, Hirschl RB, Schumacher R, Geiger JD, Cox CS, Teitelbaum DH, Polley TZ, Harmon CM, Lelli JL, Coran AG. The effect of delayed repair of congenital diaphragmatic hernia on survival. Proc Central Surgical Association 53:73, 1996.
  27. Nguyen T, Cox CS, Biondo N, Traber LD, Herndon DN, Bush PE, Traber DL. Effects of superoxide dismutase on the pulmonary response to endotoxin. Circ Shock 39 (Suppl 2):36, 1993.
  28. Allen GS, Cox CS, Cocanour CS, Duke JH, Moore FA, Andrassy RJ. Pulmonary contusions: Are children different? Proc SW Surgical Congress. (In Press)
  29. Cox CS, Black CT, Duke JH, Cocanour CS, Moore FA, Lally KP, Andrassy RJ. Operative management of truncal vascular injuries in children and adolescents. Proc Pacific Assoc of Pediatr Surg 30:109, 1997. (Poster presentation)
  30. Allen GS, Cox CS, White NW, Khalil S, Rabb M, Lally KP. Postoperative respiratory complications in ex-premature infants after inguinal herniorrhaphy. Proc Am Acad Pediatrics 49:75, 1997.
  31. Allen GS, Moore FA, Cox CS, Wilson JT, Cohn JM, Duke JH. Hollow visceral injury in blunt trauma. J Trauma 43:196, 1997.
  32. Cox CS, Allen SJ, Brennan MS. Analysis of microvascular permeability with cardiopulmonary bypass. Proc Assoc Acad Surg. 32:252, 1998. (Poster presentation)
  33. Sauer H, Cox CS, Laine GA, deVivie ER, Frederick JR, Allen SJ. Effects of TBC 1269, a novel sialyl Lewisx selectin antagonist, on the coronary microvasculature during myocardial reperfusion in a dog model. Proc FASEB. (In Press)
  34. Cox CS, Allen SJ, Brennan M. Colloids minimize intestinal edema after ongoing resuscitation. Proc Am Assoc Surg Trauma, 1999.
  35. Neville H, Lally KP, Cox CS. Emergent abdominal decompression with patch abdominoplasty in the pediatric patient. Proc Can Assoc Pediatr Surg 31:34, 1999.
  36. Cox CS, Allen SJ, Butler D, Sauer H, Frederick J. Extracorporeal circulation exacerbates microvascular permeability after endotoxemia. J Surg Res 86:283, 1999. (Oral presentation)
  37. Gill BS, Neville HL, Khan AM, Cox CS, Lally, KP. Delayed Institution of ECMO increases morbidity in meconium aspiration syndrome. Proc ELSO 11:1, 2000.
  38. Mehall JR, Cook P, Andrassy RJ, Cox CS. Incidence of missed injuries in pediatric blunt trauma patients with GCS <9. J Trauma 52:197, 2002.
  39. Stewart R, Rohn D, Fischer U, Cox CS, Allen SJ, Criscione J, Laine GA. Alterations in cardiac and vascular function curves following resolution of acute myocardial edema. FASEB J 16:A1128, 2002
  40. Cox CS, Fischer U, Allen SJ. Is mesenteric lymph toxic to endothelial cells after mesenteric ischemia/reperfusion? FASEB J 16:A442, 2002.
  41. Fischer U, Cox CS, Mehlhorn U, deVive ER, Stewart RH, Laine GA, Allen SJ. Impact of acute myocardial edema on left ventricular function. FASEB J 16:A1128, 2002.
  42. Fischer U, Allen ST, Cox CS, Stewart RH, Laine GA, Allen SJ. Effect of chronic and acute myocardial edema on left ventricular interstitial pressure and chamber compliance. FASEB J 16:A1128, 2002
  43. Cox CS, Allen SJ, Murray M. Improved myocardial function using a Na+/H+ exchange inhibitor during cardioplegic arrest and cardiopulmonary bypass. Surg Forum 52:74-77, 2001. (Oral presentation)
  44. Blakely ML, Neville HL, Mehall J, Smith S, Warner BW, Mantor PC, Cox CS, Lally, KP. A Comparison of early versus late inguinal hernia repair in premature infants. Proc Pacific Assoc. Pediatr Surg 35:48, 2002.
  45. Cox CS, Fischer UM, Allen SJ, Laine GA. Mesenteric lymph diversion prevents myocardial edema and dysfunction after gut ischemia/reperfusion (I/R). Surg Forum 195:S82, 2002. (Oral presentation)
  46. Hassoun H, Fischer U, Allen SJ, Moore FA, Laine GA, Cox CS. Regional hypothermia reduces mucosal NF-K? DNA binding activity and PMN priming via gut lymph during mesenteric ischemia/reperfusion. J Surg Res 107:316, 2002.
  47. Cox CS, Allen SA, Fischer U, Xue H, Stewart R, Laine GL, Moore FA. Gut edema causes ileus. Crit Care Med 30:A148(590), 2002. (Poster presentation)
  48. Stewart R, Quick C, Criscione J, Cox CS, Allen S, Laine G. The effect of nitric oxide on lymphatic function depends on the axial pressure gradient. FASEB J 17:A128, 2003.
  49. Miller S, Thacker L, Raney RB, Andrassy RJ, Herzog C, Lally KP, Cox CS, Blakely ML. Long-term outcome of children and adolescents with tumors of fibrous etiology. Proc ASCO A3230 (www.asco.org/ac), 2003.
  50. Fischer UM, Cox CS, Laine GA, Mehlhorn U, Allen SJ. Mild hypothermia impairs left ventricular diastolic but not systolic function. Thorac Cardiovasc Surg V192, 2003.
  51. Fischer UM, Cox CS, Laine GA, Mehlhorn U, Allen SJ. Radical Scavenging with N-Acetylcysteine reduces oxidative stress and improves cardiac performance in dogs subjected to cardioplegic arrest. Thorac Cardiovasc Surg V57, 2003.
  52. Fischer UM, Cox CS, Allen SJ, Mehlhorn U, Bloch W, Laine GA. Rapid apoptosis signal pathway induction by cardioplegic arrest. FASEB J 17:A841, 2003.
  53. Fischer UM, Cox CS, Laine GA, Mehlhorn U, Allen SJ. Acute myocardial edema does not impair left ventricular systolic function. Thorac Cardiovasc Surg V193, 2003.
  54. Fischer UM, Cox CS, Laine GA, Mehlhorn U, Bloch W, Allen SJ. Detection of altered gene expression during cardioplegic arrest by means of DNA microarray. FASEB J 17:A844, 2003.
  55. Stewart RH, Quick C, Crisione JC, Cox CS, Allen SJ, Laine GA. Hypothermia inhibits lymphatic pumping. FASEB J 17:A128, 2003.
  56. Quick C, Stewart RH, Crisione JC, Cox CS, Allen SJ, Laine GA. Lymphangion pumping can decrease lymph flow in edema: preliminary model predictions. FASEB J 17:A129, 2003.
  57. Blakely ML, Cox CS, Mathews S, Andrassy RJ, Lally KP. Acute cardiac decompensation following patent ductus arteriosus (PDA) ligation in premature infants. Surg Forum 197:S49, 2003.
  58. Moore-Olufemi SD, Xue H, Stewart RH, Laine GA, Cox CS. Gut edema alters expression of tight junction proteins. Surg Forum 199:S39, 2004.
  59. Moore-Olufemi SD, Kozar RA, Moore FA, Hassoun HT, Sato N, Cox CS, Kone BC. Ischemic preconditioning protects against intestinal ischemia/reperfusion injury. Shock 21, Supplement 2:61, 2004.
  60. Moore-Olufemi SD, Xue H, Allen SJ, Moore FA, Stewart RH, Laine GA, Cox CS. Inhibition of intestinal transit by resuscitation induced gut edema is reversed by administration of L-NIL. J Surg Res, 121:334, 2004.
  61. Harting MT, Lally KP, Cox CS, Lantin-Hermoso R, Blakely ML. Cardiac decompensation after patent ductus arteriosus ligation in premature infants. Proc Am Assoc Pediatr, 92-93, 2004.
  62. Blakely ML, Pereira KD, Cox CS, Matthews S, Lally KP. Prospective determination of the incidence of vocal cord paralysis after patent ductus arteriosus ligation. Proc Am Pediatr Surg Assoc, 35:A117, 2004.
  63. Uray K, Cox CS, Allen SJ, Laine GA. Coordinated changes in cadherin expression and contractility due to gut edema development in intestinal smooth muscle. Mol Biol Cell, Supplement 15:A2329, 2004.
  64. Uray KS, Allen SJ, Laine GA, Cox CS. Intestinal edema reduces intestinal motility through decreased myosin light chain phosphorylation. FASEB J, 19(4):A744, 2005.
  65. Harting MT, Blakely ML, Jaffe N, Cox CS, Hayes-Jordan AA, Benjamin RS, Andrassy RJ, Lally KP. Long term survival after aggressive resection of pulmonary metastases among children and adolescents with osteosarcoma. Proc Am Pediatr Surg Assoc, 36:A149, 2005.
  66. Moore-Olufemi SD, Padalecki J, Xue H, Radhakrishnan RS, Allen SJ, Stewart RH, Laine GA, Cox CS. Early enteral nutrition improves gut edema associated ileus. Surg Forum, 201:S32, 2005.
  67. Radhakrishnan R, Xue H, Moore FA, Allen SJ, Cox CS. Acute intestinal edema causes a decrease in stiffness and residual stress. Shock 23 (Supplement 3); 85:196, 2005.
  68. Khan A, Colasurdo J, Remington V, Rees M, Cox CS, Lally KP. The role of surfactant replacement during ECMO for surfactant dysfunction related to RSV bronchiolitis. Proc ELSO 16:44, 2005.
  69. Khan A, Remington V, Rees N, Hayes-Jordan A, Cox CS, Lally KP. Role of ECMO in the repair of traumatic tracheal stenosis. Proc ELSO 16:45, 2005.
  70. Radhakrishnan RS, Xue H, Weisbrodt NW, Moore FA, Allen SJ, Laine GA, Cox CS. Hypertonic saline reverses acute intestinal edema and improves transit through changes in cytoskeletal composition. J Surg Res 130:133, 2006.
  71. Radhakrishnan RS, Lally PA, Lally KP, Cox CS. ECMO for meconium aspiration syndrome: Support for relaxed entry criteria. ASAIO Journal. 52(2):66A, 2006.
  72. Radhakrishnan RS, Shah K, Xue H, Moore FA, Weisbrodt NW, Allen SJ, Gill BS, Cox CS. Minimally invasive measurement of intestinal edema using an impedance analyzer circuit. Gastroenterology 130(4 Suppl 2):A1-911, 2006.
  73. Moore-Olufemi SD, Lott S, Olufemi SE, Sato N, Kozar RA, Moore FA, Radhakrishnan RS, Cox CS, Kone BC. Transcriptional profiling of ischemic preconditioning in rat intestine following ischemia/reperfusion injury. Surg Forum. (In Press)
  74. Moore F, Mercer D, Kone B, Weisbrodt N, McKinley B, Dial E, Cox C, Kozar R, Gonzalez E, Robinson E, Moody FA. The role of the gut in multiple organ failure (MOF). Shock 25 (Suppl 1):12, 2006.
BMES Austin 2010
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