Associate Professor

Department of Biomedical Engineering
BME 5.202O
The University of Texas at Austin
Austin, Texas 78712
Phone: (512) 475-6872
E-mail Address

Lab Website

Office Hours: MWF 10-12 noon in BME 5.202O or by appointment

Research Focus

Zhang Laboratory is developing integrated photonic microsystems, semiconductor chips and nanotechnologies for imaging, sensing and regulating cellular processes critical to healthcare, environmental and defense applications. Current research focuses on developing tools and methods to understand and regulate complex biological networks critical to development and disease, and developing nano-micro fabricated photonic sensors for biomaterials characterization, fast pre-cancer detection and diagnosis. Nano-Micro scale science, Information, and Biomedicine are integrative components of Zhang's research that are used with advanced engineering tools to facilitate biomedical studies and develop point-of-care diagnostics for global health initiatives.

Research Interests   

• Micro-electro-mechanical Systems (MEMS), Semiconductors and Nanomaterials
• Micro-optical endoscopes for pre-cancer detections, nanophotonics
• Biosensors, implantable medical devices

  Selected Publications  

• T. Sharma, Y.Hu, M. Stoller, K. Lin, M. Feldman, R.S. Ruoff, M. Ferrari and X.J. Zhang, Mesoporous Silica Membrane for Ultra-thin Implantable Biofuel Cells, Lab on Chip.2011, 11(14), 2460-2465
•  L. Wang, K. Hoshino, X.J. Zhang, Near field sub-wavelength light focusing via slotted Fabry-Pérot photonic crystal with low in-plane index contrast, Optics Letters, Vol. 36, 10, 1917-1919, 2011
•  Y. Hu, A. Gopal, K. Lin, Y. Peng, X. J. Zhang, M. Ferrari, Microfluidic enrichment of small proteins from complex biological mixture on nanoporous silica chip, Biomicrofluidics, 5, 013410, 2011
•  Y. Wang, S. Bish, J. Tunnell, X.J. Zhang, MEMS Scanner Enabled Real-Time Depth Sensitive Hyperspectral Imaging of Biological Tissue, Optical Express, 18, 23, 2010.
• K. Karthik, R. Avritscher, D.C. Madoff, T. K. Yu, and X.J. Zhang, Handheld Histology-Equivalent Sectioning Laser-Scanning Confocal Optical Microscope for Interventional Imaging, Biomedical Microdevices, 12, 223-233, 2010
• E. Blinka, K. Loeffler, Y. Hu, A. Gopal, K. Hoshino, M. Ferrari and X.J. Zhang, Enhanced microcontact printing of proteins on nanoporous silica surface, Nanotechnology, 21, 415302, (9pp), 2010.
• A. Gopal, K. Hoshino, S. Kim and X. J. Zhang, Multi-color colloidal quantum dot based light emitting diodes  micropatterned  on  silicon  hole  transporting  layers,  Nanotechnology,  20,235201,  2009.
•  J. Fakhoury, J.C. Sisson, X.J. Zhang, Microsystems for controlled genetic perturbation of live Drosophila embryos – RNA interference, Development Robustness and Drug Screening, Journal of Microfluidics and Nanofluidics, 6:200-313, 2009 (Invited Review Article)
• K. Kumar, K. Hoshino,and X.J. Zhang, Handheld  subcellular-resolution single-fiber confocal microscope using high-reflectivity two-axis vertical combdrive silicon microscanner, Biomedical Microdevices 10:653-660, 2008
• A. Gopal, Z. Luo, J.Y. Lee, K. Kumar, K. Hoshino, B. Li, C. E. Schmidt, P. S. Ho and X. J. Zhang, Nano-Opto-Mechanical Characterization of Neuron Membrane Mechanics under Cellular Growth and Differentiation,  Biomedical Microdevices, 10:611-622, 2008
• K. Hoshino, L. Rozanski, D. A. Vanden Bout and X.J. Zhang, Near-field scanning optical microscopy with nanometer-sized light emitting diode, Applied Physics Letters, 92, 131106, 2008.
• K. Kumar, J.C. Condit, A. McElroy, N.J. Kemp, K. Hoshino, T.E. Milner, X.J. Zhang, Fast 3D in vivo swept source optical coherence tomography using 2-axis MEMS scanning micromirror, Journal of Optics A: Pure and Applied Optics, 10, 044013, 2008.
• K. Hoshino, L. Rozanski, D. A. Vanden Bout and X.J. Zhang, Direct fabrication of nano-scale light emitting diode on silicon probe for near-field scanning optical microscopy, IEEE/ASME Journal of Microelectromechnical Systems, p. 4-10, Vol. 17, No. 1, 2008.