James Tunnell
Assistant Professor
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James Tunnell
Assistant Professor
- Curriculum Vitae
- Department of Biomedical Engineering
The University of Texas at Austin
Austin, Texas 78712
Phone: (512) 232-2110
- Lab Website
- Office Hours: MW 3-4
Research Focus
Biomedical optical spectroscopy and imaging; early cancer detection; laser-tissue interactions; nanotechnology; nano-photonics
Research Interests
Our research focuses on developing minimally invasive optical technologies
for the diagnosis and treatment of disease, particularly for early
cancer. It is widely believed that the greatest achievement that can
be made in cancer management is the early detection and subsequent
treatment of disease. The next generation cancer management strategies
require technologies that combine sensing, targeting, and treating
of the earliest stage disease. Our approach combines optical imaging,
spectroscopy, and nanotechnology to develop systems capable of combined
diagnosis and treatment of early cancer. In addition, the lab actively
studies the basic mechanisms of light-tissue interactions to understand
light transport and develop novel imaging strategies.
The laboratory is currently recruiting students to research topics
in these areas. Please contact Dr. Tunnell for more information.
Recent and Upcoming Work
Dr. Tunnell's most recent research involved developing optical spectroscopy
as a tool for the real time detection
of early cancer in patients with
Barrett's esophagus. This research
was conducted at the G.R.
Harrison Spectroscopy Laboratory
at the Massachusetts Institute of
Technology and supported by
an NIH National
Research Service Award. Some of his recent and upcoming
presentations include:
- Engineering Conferences International,
Advances in Optics for Biotechnology,
Medicine, and Surgery. Copper
Mountain, CO, July 24-28, 2005
- 4th International Cervical Cancer Meeting. MD Anderson Cancer Center,
Houston, TX, May 19-22, 2005
- Lester
Wolfe Workshop - Massachusetts Institute of Technology,
Cambridge, MA, April 12, 2005
- NIH/AGA Symposium on Advanced Imaging and Technology in Gastrointestinal Neoplasia. Bethesda, MD, October 4-5, 2004
Selected Publications
- Diagaradjane P, Shetty A, Wang J, Elliot A, Schwartz J, Shentu S, Park HC, Deorukhkar A, Stafford J, Cho S, Tunnell
JW, Hazle J, Krishnan S. Modulation of in vivo tumor radiation response via vascular-focused hyperthermia – characterizing gold nanoshells as integrated anti-hypoxic and localized vascular disrupting agent. Nano
Lett (in press) 2008
- Park J, Estrada A, Sharp
K, Sang K, Schwartz JA, Smith D, Coleman C, Payne JD, Korgel
B, Dunn AK, Tunnell JW. Two-photon-induced photoluminescence
imaging of tumors
using near-infrared excited gold nanoshells. Opt
Express 16(3):1590-1599, 2
- Zaman RT, Diagaradjane P, Wang J, Swartz J, Rajaram N, Gill-Sharp
K, Cho S, Rylander HG, Payne DJ, Krishnan S, Tunnell
JW. In
vivo detection of gold nanoshells in tumors using diffuse optical
spectroscopy. IEEE J Sel Top Quant Elec 13(6):1715-1720, 2007
- Tunnell
JW, Desjardins A, Galindo L, Georgakoudi I, McGee SA, Mirkovic
J, Muller M, Nazemi J,
Nguyen FT, Wax A, Zhang Q, Dasari RR, Feld MS. Instrumentation
for multimodal spectroscopic diagnosis of epithelial dysplasia. Technol Cancer Res Treat 2(6):505-514,
2003. PDF
- Tunnell
JW, Haka AS, McGee SA, Mirkovic J, Feld MS. Diagnostic tissue
spectroscopy and its
applications to gastrointestinal endoscopy. Tech
Gastrointestinal Endo 5:65-73, 2003.
- Tunnell
JW, Chang D, Johnston C, Torres JH, Patrick CW, Miller MJ,
Thomsen SL, Anvari B.
Effects of cryogen spray cooling and high radiant exposures on
selective vascular injury during laser irradiation of human skin. Arch Dermatol 139:743-750, 2003. PDF
- (Editorial
Review: Anderson RR. Fire and
Ice. Arch Dermatol 139:787-788,
2003. PDF)
- Tunnell
JW, Wang L, Anvari B. Optimum pulse duration and radiant exposure
for vascular laser therapy
of dark port-wine stain skin: a theoretical study. Applied Optics 42(7):1367-1378, 2003. PDF
- Tunnell
JW, Torres JH, Anvari B. Methodology for estimation of time-dependent
surface heat flux due
to cryogen spray cooling. Ann Biomed
Eng 30:19-33, 2002. PDF
- Tunnell
JW, Nelson JS, Torres JH, Anvari B. Epidermal protection with
cryogen spray cooling
during high fluence pulsed dye laser irradiation: an ex vivo study. Lasers Surg Med 27(4):373-383,
2000. PDF
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